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. Author manuscript; available in PMC: 2019 Aug 15.
Published in final edited form as: Cancer Res. 2018 Jun 22;78(16):4563–4572. doi: 10.1158/0008-5472.CAN-18-0988

Figure 6. Model for LNC CRYBG3-actin-MAL-SRF pathway.

Figure 6.

(A&D) As one of the most important components of contractile ring, the fragmentation of the microfilament caused by LNC CRYBG3 directly leads to the inability of the contractile ring formation. Eventually the cell failed to complete the cytoplasmic division and formed binuclear cells which leads cell death. (C) In LNC CRYBG3 overexpressed cells, MAL is predominantly cytoplasmic where it is sequestered by actin monomers. (B) In control group, an accumulation of F-actin and a commensurate decrease in the level of G-actin. As a consequence, MAL is no longer sequestered and is free to translocate to the nucleus where it associates with SRF and activates SRE-mediated gene expression.