Fig. 6.

Kaempferol suppressed hepatic glucose production in HF diet-fed mice. (A) PTT was performed as described in in the Method section and the area under the curve (AUC) for PTT (B) was calculated. Primary hepatocytes were isolated from SD-fed mice (C) and HFD-fed mice (D). Cells were then cultured in gluconeogenic medium containing kaempferol, and its ability to suppress glucose production was assayed. Values are Mean ± SEM from 8-9 mice per group. Letter differences denote significant difference at P < 0.05, *, P < 0.05 vs. standard diet-fed mice (SD); #, P<0.05 vs. HF-fed mice (HF). Different letters denote P < 0.05. SD: SD diet; SD + K: SD with kaempferol treatment; HF: HF diet; HF + K: HF diet with kaempferol treatment.