Table 2.
Outcome Measures by Group over Timea
| % ASC methylation Mean (SD) |
IL-1β (pg/mL) Mean (SD) |
IL-18 (pg/mL) Mean (SD) |
6MWT (meters) Mean (SD) |
Peak V̇O2 (ml/kg/min) Mean (SD) |
|
|---|---|---|---|---|---|
| Baseline | |||||
| Control | 5.75 (0.6) | 1.88 (1.0) | 162.67 (62.1) | 330.97 (84.8) | 15.75 (4.3) |
| Exercise | 5.88 (0.9) | 1.65 (0.8) | 149.90 (33.8) | 351.97 (73.5) | 17.31 (5.2) |
| 3 Months | |||||
| Control | 5.80 (0.4) | 2.09 (1.3) | 162.86 (66.8) | 324.31 (137.3) | 16.16 (6.3) |
| Exercise | 6.10 (0.5)*† | 1.43 (0.5)*† | 138.18 (56.0) | 372.22 (64.5)* | 16.61 (4.2) |
| 6 Months | |||||
| Control | 5.82 (0.4) | 2.13 (1.4) | 160.58 (34.7) | 324.29 (128.3) | -- |
| Exercise | 6.07 (0.4)* † | 1.49 (0.5)*‡§ | 130.15 (52.9) | 387.33 (56.2)*‡ | -- |
a
PROC MIXED with least squares mean analysis adjusting with Bonferroni was used to compare within GROUP and between GROUP changes across TIME.
*
Group differences significant at p<.05.
†
Difference from baseline is significant at p<.01.
‡
Difference from baseline significant at p<.05.
§
Difference from 3 months significant at p<.05.
ASC – Apoptosis associated speck-like protein containing a caspase recruitment domain
IL - Interleukin
6MWT – Six-minute walk test