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. Author manuscript; available in PMC: 2019 Aug 1.
Published in final edited form as: J Nutr Biochem. 2018 May 12;58:59–70. doi: 10.1016/j.jnutbio.2018.04.018

Fig. 5.

Fig. 5

The anti-apoptotic effect of genistein was independent of ERα and ERβ. (A) Co-incubation of human islets with ER inhibitor ICI 182,780 (ICI, 10 μM) blocked the effect of 17β-estradiol (E2; 0.1μM), but no that of genistein (Gen, 1 μM), on high glucose (Glu, 20 mM) and palmitate (PA, 0.5 mM) induced islet apoptosis. (B) Genistein (G, 5 μM) and its non-estrogenic analog daidzein (D, 5 μM) protected human islets from high glucose (Glu; 20 mM) and palmitate (PA; 0.5 mM) induced apoptosis. *, p<0.05 (n= 4±SEM).