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. 2018 Jun 18;159(9):1856–1866. doi: 10.1097/j.pain.0000000000001282

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Figure 2. — Neuropathic pain–induced deficits in hypersensitivity and anhedonia. (A) Repeated-measures 2-way ANOVA analysis of mechanical thresholds yielded a significant group × time effect (F_2,86 = 94.7, P < 0.001). Although post hoc assessment showed no difference in mechanical threshold between the 2 groups before surgery, at both 1 week and 3 months after surgery, nerve-injured rats had a significantly lower withdrawal thresholds compared with controls. (B) A significant group × time effect (F_2,86 = 17.5, P < 0.001) was also found for cold sensitivity. Post hoc analysis showed significant differences between groups at both postsurgery time points but not at baseline. (C) Repeated-measures 2-way ANOVA analysis of sucrose preference yielded a significant group × time effect (F_1,43 = 5.02, P = 0.030). Data are presented as mean ± SEM. ***P < 0.001 compared with control group. ANOVA, analysis of variance; BL, baseline; SNI, spared nerve injury.