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. Author manuscript; available in PMC: 2019 Sep 1.
Published in final edited form as: Pain. 2018 Sep;159(9):1802–1813. doi: 10.1097/j.pain.0000000000001277

Figure 2. Immunoneutralization of C-terminal VGF peptides delays the progression of peripheral nerve injury-induced mechanical hypersensitivity.

Figure 2

A) Spared Nerve Injury (SNI) mice treated with anti-AQEE30 at the time of injury show decreased mechanical hypersensitivity at 1, 2, 3 and 7 days post-injury compared to mice treated with control IgG (GP IgG) or untreated mice (No Tx). B) In a separate cohort of mice, mechanical hypersensitivity is reduced in SNI mice treated with anti-AQEE30 (0.5 or 1 μg) compared to controls for 12 days post injury but is fully manifest by 19 days post-surgery. Data are represented as mean +/− SEM. *, **, ***, **** = P<0.05, P<0.01, P<0.001, P<0.0001 compared to No Tx control by ipsilateral two-way ANOVA with Dunnett’s post test.