Fig. 3.

Grade ≥3 general gastrointestinal (GI) toxicity as a function of the prescription (Rx) physical dose to the target, with the probit model result (maximum likelihood parameter fitting) and 95% and 68% confidence intervals (CIs). General GI toxicities were defined as fatigue, nausea, diarrhea, gastritis, ulcers, GI area pain, and colitis. The target RX dose definition is provided in Table 2. Each data point is placed at the reported mean or median dose and reported complication rate; the horizontal error bars represent the reported ranges, and the vertical error bars represent binomial 68% CIs. The number of patients who developed toxicity out of the total number of patients for each study is displayed next to the data point. Abbreviation: LML = log maximum likelihood.