Table 1.

CBVa values reported in the literature.

Reference	Species	Brain Region	Technique	CBVa (ml/100 ml)
(Neil and Ackerman, 1992)	Rat	Whole brain	MRI	1.00±0.15
(Duong and Kim, 2000)	Rat	Whole brain	19F NMR	0.9±0.2
(Lee et al., 2001)	Rat	Whole brain	19F NMR	0.78
(Ito et al., 2001)	Human	Cortex	PET	1.1±0.4
(Barbier et al., 2001)	Rat	Cortex	MRI	0.82±0.10
(An and Lin, 2002b)	Human	Whole brain	MRI	0.74±0.20
(Ito et al., 2005)	Human	Cortex	PET	1.5±0.3
(Kim and Kim, 2005, 2006)	Rat	Cortex	MRI	1.1±0.5
		Caudate, Putamen		1.3±0.6
(Petersen et al., 2006)	Human	Gray matter	MRI	0.93±0.0
(Kim et al., 2007)	Rat	Somatosensory cortex	MRI	0.83±0.21
(Brookes et al., 2007)	Human	Gray matter	MRI	1.7±0.1
(Hendrikse et al., 2008)	Human	Anterior border zone	MRI	0.88±0.07
		Posterior border zone		1.19±0.11
		Non-border zone GM		1.64±0.08
(Petersen et al., 2010)	Human	Gray matter	MRI	0.67±0.16
(Hua et al., 2011b)	Human	Gray matter	MRI	0.76±0.17
(Yan et al., 2012)	Human	Gray matter	MRI	1.14 – 2.05
		White matter		0.46 – 0.55
(Heijtel et al., 2016)	Human	Gray matter	MRI	0.84±0.35
			PET	3.21±0.45
		White matter	MRI	0.54±0.26
			PET	1.87±0.31
		Whole brain	MRI	0.70±0.31
			PET	2.60±0.38
(Kim et al., 2016)	Human	Gray matter	MRI	1.4 – 2.3
(Rane et al., 2016)	Human	Cortex	MRI	1.58 – 1.89
		Hippocampus		2.20 – 2.32

The percentage of CBVa/CBVtot depends on the CBVtot value used, which was estimated to be approximately 20–30% in (Piechnik et al., 2008; Sharan et al., 1989; van Zijl et al., 1998).