Table 5.
Relationship between CBF and CBV changes during functional and physiological stimulation in arterial and venous vessels reported in the literature.
| Reference | Species | Anesthesia | Stimulation | Technique | Flow-volume coupling | |
|---|---|---|---|---|---|---|
| Type | Duration | |||||
| (Lee et al., 2001) | Rat | α-chloralose | Hypercapnia | N/A | 19F NMR, microscopy | |
| CBVtot ~ CBF0.40 or ΔrCBVtot/ΔrCBF = 0.31, ΔrCBVa/ΔrCBF = 0.79, ΔrCBVv/ΔrCBF = 0.15 | ||||||
|
| ||||||
| (Kim et al., 2007) | Rat | isoflurane | Forepaw stimulation | 15 s | MRI | |
| ΔrCBVtot/ΔrCBF = 0.45 and ΔrCBVa/ΔrCBF = 1.86 | ||||||
|
| ||||||
| (Chen and Pike, 2009a) | Human | N/A | Visual and sensorimotor | 96 s | MRI | |
| CBVv ~ CBF0.23±0.05 | ||||||
|
| ||||||
| (Chen and Pike, 2010) | Human | N/A | Hypercapnia, hypocapnia | 180 s | MRI | |
| CBVv ~ CBF0.18±0.02 | ||||||
|
| ||||||
| (Hua et al., 2010; Hua et al., 2011c) | Human | N/A | Visual | 15 s | MRI | |
| CBVtot ~ CBF0.52±0.04, CBVa ~ CBF0.86±0.05, CBVv ~ CBF0.42±0.03 | ||||||
|
| ||||||
| (Hua et al., 2010; Hua et al., 2011c) | Human | N/A | Breathhold | 15 s | MRI | |
| CBVtot ~ CBF0.90±0.05, CBVa ~ CBF0.86±0.05, CBVv ~ CBF0.90±0.05 | ||||||