Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 May 10;37(33):4518–4533. doi: 10.1038/s41388-018-0295-z

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 1 — High MASTL expression correlates with poor overall survival in breast cancer. a The percentage of genomic alterations of MASTL across the spectrum of human cancers currently annotated in the TCGA provisional databases (cBioportal). b Correlation (Pearson) between the expression of CIN25 gene signature and MASTL in 880 breast tumour cases in the TCGA. c Breast cancer tumours from a cohort of 473 patients were stained and scored for MASTL protein expression and overall survival, Kaplan–Meier curves for high and low MASTL expression generated. Representative micrographs of low and high MASTL shown. d, e MASTL expression compared with other clinicopathological features; MASTL expression is significantly higher with mitotic index, histological grade and the Basal breast cancer subtype (one-way ANOVA, mean ± S.D, n = 473, ****p < 0.0001, *p < 0.05). f Correlation between MASTL expression and Ki67 staining intensity in TMA cohort (Pearson’s r correlation, 0.4522, n = 432). g Western blot analysis of MASTL protein expression in a range of non-tumorigenic (blue) and tumorigenic breast cancer cell lines (red). h Comparison of MASTL protein mRNA expression (TaqMan RT-PCR) from normal and breast cancer cell lines. All values normalised to MCF10A protein and mRNA levels