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. 2018 Aug 16;8:12262. doi: 10.1038/s41598-018-30764-4

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Explained variation of metabolites by macro- and micronutrients: adjusted R²-values comparing the multivariable adjusted models without and with interaction terms for fasting time included. The multivariable model was adjusted for sex, age, BMI, smoked pack-cigarettes per year and physical activity. ess_aa=indispensable amino acids; none_aa=dispensable amino acids; sc_acylC=short-chain acylcarnitines; mc_acylC=medium-chain acylcarnitines; lc_acylC=long-chain acylcarnitines; sat_PC=saturated phosphatidylcholines; mo_PC=monounsaturated phosphatidylcholines, po_PC= polyunsaturated phosphatidylcholines; SM=Sphingolipids; lysoPC=lyso-phosphatidylcholine and H=Hexose.