Table 2.
Evaluation of α-klotho, FGF-23, IL-6, TNF-α, PLT and BDNF as potential serum biomarkers for the diagnosis of hemodialysis-induced mild cognitive decline.
| Evaluation index | cut-off value | Sensitivity | Specificity | Positive predictive value | Negative predictive value | Accuracy |
|---|---|---|---|---|---|---|
| α-klotho, (n) | 469.5 pg/ml | 41.4% (12/29) | 44.8% (13/29) | 42.9% (12/28) | 43.3% (13/30) | 43.1% (25/58) |
| FGF-23, (n) | 1264.5 ng/ml | 62.1% (18/29) | 31.0% (9/29) | 64.3% (18/28) | 30.0% (9/30) | 46.6% (27/58) |
| IL-6, (n) | 1.8 pg/ml | 17.2% (5/29) | 44.8% (13/29) | 17.9% (5/28) | 43.3% (13/30) | 31.0% (18/58) |
| TNF-α, (n) | 21.1 pg/ml | 37.9% (11/29) | 10.3% (3/29) | 39.3% (11/28) | 10.0% (3/30) | 24.1% (14/58) |
| PLT, (n) | 158.5 × 109/L | 51.7% (15/29) | 17.2% (5/29) | 38.5% (15/39) | 26.3% (5/19) | 35.0% (20/58) |
| BDNF, (n) | 20.0 ng/ml | 13.8 (4/29) | 65.5 (19/29) | 28.6 (4/14) | 43.2 (19/44) | 40.0 (23/58) |
BDNF: brain-derived neurotrophic factor; FGF-23: fibroblast growth factor-23; IL-6: interleukin-6; MCD: mild cognitive decline; PLT: platelet; ROC: receiver operating characteristic; TNF-α: tumour necrosis factor-α.