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. 2018 Aug 16;8:12290. doi: 10.1038/s41598-018-29642-w

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Relation of NIS expression and radioiodine uptake to proteasome activity. (A) Proteasome activity (left), NIS expression (middle) and ¹²⁵I uptake (right) in CT26/NIS-cODC cells exposed for 16 h to graded doses of bortezomib. Blots are cropped for representative blots and quantified as mean ± SD in fold of controls of duplicate band intensities normalized to β-actin bands. For full length blot pictures, see Supplement Fig. 4. Bars on the right are mean ± SD of % uptake of triplicate samples. ^‡P < 0.001, **P < 0.01, **P < 0.05, compared to controls. (B) Correlations between NIS expression (left) or ¹²⁵I uptake (middle) and log proteasome activity, and between NIS expression and ¹²⁵I uptake (right). Proteasome activity is measured as rate of increase in fluorescent intensity (arbitrary units). Correlation coefficients (r) and P values are from regression analysis.