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. 2018 Aug 16;8:12290. doi: 10.1038/s41598-018-29642-w

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Treatment response of CT26/NIS-cODC clones and relation to NIS transport. (A) Surviving fraction of clone #1 and #9 (left) or clone #8 and #20 (right) in comparison to CT26 cells after 72 h treatment with graded doses of bortezomib. Bars are mean ± SD of % survival of quadruplicate samples. (B) Linear correlation between ¹²⁵I (left) or ^99mTc-0₄⁻ uptake (right) at 48 h of exposure to 25 nM bortezomib and cytotoxic effects of 72 h treatment with 25 nM (top) or 50 nM bortezomib (bottom) in four different stable CT26/NIS-cODC clones. Bars are mean ± SD of % uptake of quadruplicate samples. Correlation coefficients (r) and P values are from linear regression analysis of quadruplicate samples for each stable clone.