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. 2018 Aug 16;8:12290. doi: 10.1038/s41598-018-29642-w

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Tumor NIS staining and radioiodine uptake level. (A) Immunohistochemistry for NIS expression in tumor tissues extracted after imaging. (B) In vivo tumor-to-background SUVmax ratios obtained from PET (left), and ex vivo tumor-to-muscle (tm/muscle) count ratios (middle). Bars are mean ± SD of values obtained from mice with CT26 tumors (n = 5) and mice with CT26/NIS-cODC tumors treated with vehicle (n = 6) or bortezomib (n = 8). Correlation between in vivo and ex vivo measured uptake indices with Spearman’s correlation coefficient (rho; right).