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. 2018 Aug 16;8:12271. doi: 10.1038/s41598-018-29924-3

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Impaired cell cycle progression in mice with defective cytosolic nucleic acid sensing pathways. Total protein extracts of liver samples were analysed by Western blotting using antibodies against cyclin D1, cyclin E1, p-RB, p-CDK2, or CDK1. Representative gels (A) and densitometric analyses (B) are depicted. Cropped gels are shown. Full length gels are available in the supplemental information. Hepatic mRNA expression of cyclin D1 (C) as well as cyclins A2 and B1 (D) is depicted as fold difference relative to untreated livers. For each time point and in each group samples from 4 to 8 independent mice were analysed. *P < 0.05, **P < 0.01 ***P < 0.001 (two-tailed unpaired Student’s t-test or the Mann-Whitney U test).