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. 2018 Aug 16;8:12252. doi: 10.1038/s41598-018-29708-9

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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miR-342-3p is down-modulated in TN tumors and associated to oncogenic features and poor clinical outcomes. (a) Heatmap and hierarchical clustering of miRNAs differentially expressed between TN tumors vs other phenotypes. (b) Pathway enrichment analysis of miRNAs-mRNAs altered in triple negative tumors. (c) RT-qPCR expression of miR-342-3p in breast cancer cell lines. The panel of cell lines showed a heterogeneous miR-342-3p expression with a significant down-modulation in basal A and B cell lines. Kruskal-Wallis test showed the statistical significance between the multiple phenotype comparisons. Expression level of miR-342-3p in (d) TCGA and (e) METABRIC databases across IHC subtypes, TN tumors: ER−, PR− Her2−, Her2 tumors: ER−, PR− and Her2+ and luminal tumors: ER/PR+ , Her2− or ER/PR+, Her2+ (f) Survival analysis according to miR-342-3p expression. Lower miR-342-3p expression levels is associated with a decreased overall survival in patients with triple negative breast cancer. Kaplan-Meier survival curve shows patients with lower miR-342-3p expression (≤1st quantile) in blue line and higher miR-342-3p expression (>to 1st quantile) in red line.