Fig. 4.

Emerging PfCRT mutations modify P. falciparum susceptibility to multiple antimalarial drugs. Mean ± SEM IC₅₀ values (Supplementary Tables 7–10) were calculated from 72-h dose–response assays for drugs designated in a–g. N, n = 4+, 2. Significance was determined using Mann–Whitney U tests comparing pfcrt-edited parasites and their isogenic controls. *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001; n.s. not significant, md monodesethyl