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. 2018 Aug 17;9:3314. doi: 10.1038/s41467-018-05652-0

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — pfpm2 amplification is not essential for PPQ resistance but may be associated. qPCR-based determination of pfpm2 copy number, shown as means ± SEM. Results showed the presence of only one pfpm2 copy in PPQ-resistant genetically edited Dd2 lines that expressed novel pfcrt alleles. The multiple pfpm2 copies observed in the Cambodian lines PH1008-C and PH1263-C were reduced to single copies upon removal of the PfCRT M343L or H97Y mutations. These data were consistent with the decrease in RNA expression levels observed by RT-qPCR (Supplementary Table 13)