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. 2018 Aug 16;8:12295. doi: 10.1038/s41598-018-30541-3

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Cysteamine-capped AuNPs induce cell death by altering Wnt signalling pathway and epigenetic changes in MDA-MB-231 cells. (A) Western blots and densitometric analysis of p-p38, p38, p-GSK-3β, GSK-3β, β-catenin and Cyclin D1 when treated with cysteamine-capped AuNPs of 100 μg/mL, 250 μg/mL and 500 μg/mL for 24 h (B) Western blots and densitometric analysis of MKP-1, H3 ser 10 phosphorylation and H3 (K9/K14) acetylation in MDA-MB-231 cells when treated with cysteamine-capped AuNPs of 100 μg/mL, 250 μg/mL and 500 μg/mL for 24 h. α-tubulin and H3 were used as loading control for our experiments. Results shown were representative of three different experiments. Blots of the same gel have been grouped. After checking the expression of p-p38, p-GSK-3β and histone H3 modifications, stripping was performed and the same blots were reprobed with p38, GSK-3β and total H3 antibodies. Blots of these were also grouped. Uncropped images of the blots have been shown in supplementary information. All values were expressed as mean ± S.E.M. **p < 0.01, ***p < 0.001 significant vs control.