Table 3.
Factors associated with progression of liver disease in chronic hepatitis B patients.
| HBV chronic infection group (n = 175) | Chronic hepatitis B group (n = 93) | OR | 95% CI | P value | |
|---|---|---|---|---|---|
| Age, years | 42 [33.2–50.8] | 41 [34.0–51.5] | 1 | 0.98–1.02 | 0.827 |
| Male sex | 95 (55.2%) | 66 (71.7%) | 1.15 | 0.99–1.84 | 0.013 |
| ALT, (IU/L) | 45 [33.0–45.0] | 80 [62.0–92.0] | 0.74 | 0.64–0.86 | <0.001 |
| AST, (IU/L) | 35 [31.0–35.0] | 70 [48.0–105] | 0.84 | 0.79–0.91 | <0.001 |
| Viral Load log10 (IU/mL) | 2.90 [2.47–3.30] | 4.65 [3.86–6.11] | 1 | 1.00–1.00 | <0.001 |
| HBV genotype D | 164 (93.7%) | 84 (90.3%) | 1.55 | 0.50–5.36 | 0.615 |
| MBOAT7 rs641738 TT genotype | 42 (24%) | 25 (26.7%) | 0.81 | 0.41–1.61 | 0.547 |
ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; MBOAT7: membrane bound O-acyltransferase domain containing 7 gene; OR: Odds ratio; CI: confidence interval.