Table 4.

Factors associated with liver fibrosis F3-F4 in chronic hepatitis C patients.

	F0–F2 group (n = 92)	F3-F4 group (n = 196)	OR	95% CI	p-value
Age, years	58.5 [51–67]	65 [58–73]	1.06	1.04–1.09	<0.001
Male sex (%)	23 (25.0%)	81 (41.3%)	2.1	1.23–3.71	0.011
Serum cholesterol, (g/L)	1.64 [1.36–1.85]	1.42 [1.25–1.67]	0.23	0.07–0.75	0.013
HDL, (g/L)	0.52 [0.42–0.66]	0.47 [0.37–0.60]	0.14	0.01–1.73	0.213
LDL, (g/L)	0.89 [0.60–1.15]	0.80 [0.50–0.92]	0.42	0.10–1.68	0.163
Triglycerides, (g/L)	0.96 [0.81–1.27]	0.98 [0.78–1.21]	1.12	0.41–3.06	0.805
Gamma-glutamyltransferase, (IU/L)	27.0 [19.0–40.0]	63.0 [37.5–114]	1.02	1.01–1.03	<0.001
ALT, (IU/L)	40.5 [28.2–61.8]	80 [52.5–122]	1.02	1.01–1.04	<0.001
AST, (IU/L)	33.5 [27.0–44.2]	71.0 [54.0–117]	1.04	1.02–1.06	<0.001
MBOAT7 rs641738 TT genotype	19 (20.7%)	35 (17.9%)	1.12	0.55–2.28	0.761

HDL: High density lipoprotein; LDL: low density lipoprotein; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; MBOAT7: membrane bound O-acyltransferase domain containing 7 gene; OR: Odds ratio; CI: confidence interval.