Figure 5.

Amelioration of Renal Fibrosis following p53 Deletion

The body weights of the mice (A). Blood and urine samples are collected for glucose (B), serum creatinine (C), and urinary ACR (D) measurements. Renal cortical tissues are collected for H&E staining and Masson staining (E), quantification of glomerular damage score (F), tubular damage score (G), and tubulointerstitial fibrosis (H) in the kidney cortex. Original magnification, ×200. Bar, 100 μm. Data are expressed as means ± SD (n = 8). #p < 0.05, STZ-treated PT-p53-WT group versus saline-treated PT-p53-WT group; *p < 0.05, STZ-treated PT-p53-KO group versus saline-treated PT-p53-KO group.