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. 2018 Aug 10;9:900. doi: 10.3389/fphar.2018.00900

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Copyright © 2018 Yang, Guo, Dong, Sheng, Wang, Yu, Wang and Tang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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MCP-1 and miR-374a expression in DN tissues. qRT-PCR analysis of MCP-1 mRNA (A) and miR-374a (B) levels in DN tissues. (C) Spearman’s correlation analysis demonstrating an inverse correlation between miR-374a and MCP-1 mRNA levels. ^∗P < 0.05. (D) Histological analysis of normal (n = 5) and DN (n = 10) tissues, as determined by HE staining. (E) Upregulation of MCP-1 in DN tissue, as determined by immunohistochemistry. HG induced MCP-1 but suppressed miR-374a in HK2 cells. (F) qRT-PCR and (G) western blot analysis of MCP-1 expression in HK2 cells treated with NG, HG, or HO for 24 h. ^∗P < 0.05 vs. NG or HO group (n = 3). (H) miR-374a expression in each group as determined by qRT-PCR. ^∗P < 0.05 vs. NG group (n = 3).