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. 2018 Aug 10;9:1833. doi: 10.3389/fimmu.2018.01833

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Copyright © 2018 Kopecki, Stevens, Chong, Yang and Cowin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Reduced Flii expression leads to decreased development of OVA-induced atopic dermatitis (AD)-like lesions. (A) Ovalbumin (OVA) exposure protocol, including a total of three 1-week exposures to 100 µl 0.1% OVA or saline control on patches separated from each other by 2-week resting interval. (B) Representative clinical images of OVA-induced AD-like skin lesions in mice differential Flii expression illustrating high degree of erythema, skin thickening, and scaling (black arrowhead) in WT and Flii^Tg/Tg mice exposed to OVA. (C,D) OVA exposure leads to development of AD-like lesions demonstrated by increased erythema and transepidermal water loss (TEWL). Decreasing Flii expression reduces development of AD-like lesions with significantly decreased erythema and TEWL measurements compared to OVA exposed skin of WT and Flii^Tg/Tg animals. n = 8. Mean ± SEM. *<0.05.