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. 2018 Aug 10;9:1833. doi: 10.3389/fimmu.2018.01833

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Copyright © 2018 Kopecki, Stevens, Chong, Yang and Cowin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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OVA-induced atopic dermatitis (AD) skin-like lesions of Flii-deficient mice exhibit increased anti-inflammatory cytokine levels. mRNA levels of Flii, pro-inflammatory, and anti-inflammatory cytokines responsible for manifestation of AD were analyzed in the OVA-induced AD skin-like lesions of Flii^+/−, wild-type, and Flii^Tg/Tg animals. OVA-induced AD skin-like lesions of Flii-deficient mice have significantly higher IFN-γ, reduced IL-4 signaling, and significantly higher levels of anti-inflammatory IL-10 while the Flii transgenic counterparts show significantly increased TNF-α and significantly reduced IFN-γ compared to wild-type animals. n = 6. Mean ± SEM. *<0.05.