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. 2018 Aug 10;9:1833. doi: 10.3389/fimmu.2018.01833

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Copyright © 2018 Kopecki, Stevens, Chong, Yang and Cowin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Flii expression affects Th₂ chemokine levels in OVA-induced atopic dermatitis (AD) skin-like lesions. mRNA levels of CCL17, CCL22, and CXCL9 chemokines responsible for manifestation of AD were analyzed in the OVA-induced AD skin-like lesions of Flii^+/−, wild-type, and Flii^Tg/Tg animals. OVA-induced AD skin-like lesions of Flii^+/− mice have significantly higher levels of CCL17 compared to Flii^Tg/Tg counterparts, while CCL22 was significantly increased in OVA-induced AD skin-like lesions of Flii^Tg/Tg mice compared to wild-type controls. n = 6. Mean ± SEM. *<0.05.