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. 2018 Aug 10;9:1088. doi: 10.3389/fphys.2018.01088

FIGURE 1.

FIGURE 1

Physiological calcium handing (A–E) and hypothesis for calcium handing with loss-of-function of sodium channel (F–J) during cardiac excitation and relaxation. NCX: Na+/Ca2+ exchanger-1; NaV1.5: sodium channel; LTCC: L-type calcium channel; RyR: Ryanodine receptor; SERCA: sarco(endo)plasmic reticulum Ca2+-ATPase 2a; PLN: phospholamban.