Table 1.

Somatic mutations identified in the primary tumor, metastasis and plasma.

Gene	Chr: position	Ref allele	Mut allele	Codon change	Protein change	Variant type	VAF%
							Tumor	Metastasis	PS1
KRAS	chr12: 25398284	C	A	c.35G>T	p.Gly12Val	Missense	43.28	35.86	23.23
TP53	chr17: 7578406	C	T	c.524G>A	p.Arg175His	Missense	80.23	61.35	28.27
RB1	chr13: 49033902	T	C	c.2039T>C	p.Ile680Thr	Missense	11.11	1.08	ND
ALK	chr2: 29443666	C	T	c.3551G>A	p.Gly1184Glu	Missense	25.89	ND	ND
ERBB2	chr17: 37881388	A	G	c.2580A>G	p.Lys860Lys	Synonymous	19.66	ND	ND

Chr, chromosome; Ref, reference allele; Mut, mutated allele; VAF, variant allele frequency; PS1, plasma sample #1 (pretreatment) ND, not detected.