Table 7.
Differently expressed genes annotated “IGF1 Signaling” pathway.
| Gene name | Gene Symbol | GC*from PDF mean FPKM value | p-value | GC*from PMF FPKM value | p-value | Significance, paired t-test | Fold-change down |
|---|---|---|---|---|---|---|---|
| SIGNIFICANTLY DOWN-REGULATED IN GRANULOSA CELLS DURING PRIMORDIAL TO PRIMARY TRANSITION | |||||||
| Protein Kinase C Iota | PRKCI | 4,140 | 0,027 | 1,999 | 0,410 | 0,226 | 2,071 |
| Caspase 9 | CASP9 | 0,357 | 0,192 | 0 | 0 | Significant | ∞ |
| Insulin Like Growth Factor Binding Protein 3 | IGFBP3 | 3,356 | 0,067 | 0,784 | 0,423 | 0,003 | 4,280 |
| Suppressor Of Cytokine Signaling 2 | SOCS2 | 1,768 | 0,186 | 0,300 | 0,307 | 0,318 | 5,894 |
| Janus Kinase 2 | JAK2 | 5,792 | 0,022 | 1,436 | 0,423 | 0,123 | 4,034 |
| SIGNIFICANTLY UP-REGULATED IN GRANULOSA CELLS DURING PRIMORDIAL-PRIMARY TRANSITION | |||||||
| Phosphatidylinositol 3-Kinase Catalytic Subunit Type 3 | PIK3C3 | 3,254 | 0,198 | 3,822 | 0,170 | 0,033 | 0,851 |
Differently expressed genes identified by comparing transcriptomes of the granulosa cells from primordial follicles vs. granulosa cells from primary follicles. Five genes were significantly downregulated, and one gene was significantly upregulated during the primordial to primary follicle transition. Significance: fold-change >2 and/or paired t-test significance (p < 0.05) between the two FPKM mean values.
*
Granulosa cells.