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. 2018 Aug 10;9:1804. doi: 10.3389/fimmu.2018.01804

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Copyright © 2018 Biguetti, Vieira, Cavalla, Fonseca, Colavite, Silva, Trombone and Garlet.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Micro-computed tomography (μCT) analysis along intramembranous bone healing in wild-type (WT) vs CCR2KO mice. Maxillae containing dental sockets post-extraction from WT and CCR2KO mice were scanned with the μCT System (Skyscan 1174; Skyscan, Kontich, Belgium). (A) Three-dimensional images obtained by CT-Vox software reveal the socket morphology at 0 h, 7, 14, and 21 days post tooth extraction. (B) Morphological parameters such as bone volume fraction (BV/TV, %), trabecular number (Tb.N, 1/mm), trabecular separation (Tb.Sp, mm), and trabecular thickness (Tb.Th, mm) were quantified at 7, 14, and 21 days post tooth extraction. Results are presented as mean and SD to different parameters. Different letters indicate significant differences in each time point (p < 0.05); symbol * indicate significant differences between WT vs CCR2KO at the same time point.