Figure 1.

Impact of allergic asthma sensitization on the course of Brucella infection in wild-type mice. Wild-type BALB/c and C57BL/6 mice received repeated i.n. administration of phosphate-buffered saline, HDM, or Alt before i.n. infection with 2 × 10⁴ CFU of mCherry-Brucella melitensis (A,B) or 2 × 10³ CFU of B. melitensis, B. abortus, or Brucella suis (C), as indicated in the figure and in the Section “Materials and Methods.” The mice were sacrificed at the selected time post infection. The data represent the number of CFU/gr of lung, spleen, and liver. n denotes the number of mice used for each lineage. These results are representative of at least two independent experiments. **p < 0.01, ***p < 0.001.