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. 2018 Aug 10;9:1855. doi: 10.3389/fimmu.2018.01855

Figure 7.

Figure 7

Inverse correlation between KIR3DL1− natural killer (NK) cell activation or human immunodeficiency virus type 1 (HIV-1)-specific KIR3DL1−CD8 T-cell responses and viral load (VL) set point in Bw4-homozygous individuals. (A) Gating strategy for flow cytometric analysis of CD69 and KIR3DL1 expressing on NK cells; (B) comparison of the proportion of CD69+NK and KIR3DL1−CD69+NK cells between HIV-1-infected individuals homozygous for Bw4 (red) and Bw6 (blue). Inverse correlation between the frequency of CD69+NK cells (C), KIR3DL1−CD69+NK cells (D) and HIV-1 VL set point, and even HIV-1 VL at 3 years after infection (E) in Bw4-homozygous individuals; negative correlation of the frequency of HIV-1-specific KIR3DL1−CD107a+CD8+ T cells with HIV-1 VL set point (F) and HIV-1 VL at 3 years after infection (G) in Bw4-homozygous participants; correlation between the KIR3DL1−NK cells activation capacity and the frequency of HIV-1-specific KIR3DL1−CD107a+CD8+ T cells (H); inverse correlation between the frequency of CD69+NK cells and the amounts of HIV-1-specific IFN-γ+CD8+ T cells (I), between the frequency of KIR3DL1−CD69+NK cells and the amounts of HIV-1-specific KIR3DL1−IFN-γ+CD8+ T cells (J) were shown. Comparisons between two groups were performed with unpaired Student’s t-tests and correlations between two variables were assessed in non-parametric Spearman’s rank correlation tests, with P < 0.05 considered significant.