Table 1.
Demographics of HIV-1-infected individuals.
| Age | VL set point, Log10 (copies/ml) | CD4 T-cell count (cells/μl) | HLA-*B alleles | VL at 3 years after infection, Log10 (copies/ml) | CD4 decline to <350 within 3 years | |
|---|---|---|---|---|---|---|
| Bw4/4 | ||||||
| 1 | 34 | 4.37 | 374 | B*37, B*51 | 4.29 | Y |
| 2 | 23 | 3.84 | 1,058 | B*51, B*51 | 4.54 | N |
| 3 | 25 | 2.94 | 919 | B*57, B*27 | 3.10 | N |
| 4 | 26 | 5.19 | 117 | B*58, B*51 | NDa | Y |
| 5 | 27 | 4.43 | 602 | B*13, B*27 | 5.06 | N |
| 6 | 28 | 3.87 | 455 | B*13, B*13 | NDa | Y |
| 7 | 47 | 4.04 | 561 | B*13, B*13 | 4.43 | N |
| 8 | 26 | 3.62 | 820 | B*37, B*58 | 5.02 | Y |
| 9 | 24 | 3.41 | 668 | B*44, B*52 | 4.04 | N |
| 10 | 41 | 3.68 | 345 | B*27, B*52 | 3.94 | Y |
| 11 | 24 | 2.50 | 345 | B*44, B*58 | 3.75 | N |
| 12 | 22 | 4.82 | 546 | B*44, B*38 | 5.02 | Y |
| 13 | 21 | 3.09 | 505 | B*44, B*57 | 3.23 | N |
| 14 | 46 | 2.81 | 505 | B*44, B*13 | 3.07 | N |
| 15 | 47 | 3.85 | 498 | B*44, B*13 | 4.77 | N |
| 16 | 34 | 2.95 | 933 | B*52, B*52 | 3.21 | N |
| 17 | 31 | 3.94 | 530 | B*44, B*13 | 1.88a | N |
| Mean ± SD | 30.9 ± 9.0 | 3.73 ± 0.73 | 575 ± 242.2 | |||
| Bw6/6 | ||||||
| 18 | 39 | 4.24 | 358 | B*15, B*15 | 3.65 | Y |
| 19 | 42 | 4.90 | 222 | B*15, B*35 | 3.71a | Y |
| 20 | 56 | 4.40 | 513 | B*08, B*54 | 4.39 | Y |
| 21 | 25 | 3.27 | 827 | B*39, B*15 | 3.82 | N |
| 22 | 24 | 3.40 | 303 | B*40, B*67 | 4.67 | Y |
| 23 | 27 | 4.66 | 899 | B*15, B*67 | 4.17 | Y |
| 24 | 38 | 5.24 | 258 | B*40, B*15 | 5.16 | N |
| 25 | 39 | 4.30 | 196 | B*40, B*15 | 4.07 | Y |
| 26 | 39 | 4.04 | 454 | B*07, B*15 | 3.95 | N |
| 27 | 49 | 5.07 | 281 | B*08, B*15 | 4.84 | Y |
| 28 | 25 | 4.88 | 351 | B*46, B*15 | 4.35 | Y |
| 29 | 23 | 4.85 | 205 | B*55, B*15 | NDa | Y |
| 30 | 36 | 5.23 | 554 | B*40, B*46 | 5.28 | Y |
| 31 | 34 | 4.60 | 516 | B*48, B*40 | 5.40 | Y |
| 32 | 27 | 4.42 | 770 | B*08, B*45 | 4.18 | Y |
| 33 | 54 | 4.30 | 308 | B*07, B*35 | NA | –b |
| 34 | 25 | 4.46 | 353 | B*07, B*48 | 3.15a | Y |
| Mean ± SD | 35.4 ± 10.6 | 4.48 ± 0.56 | 433 ± 219.6 | – | – | |
| P value | 0.195c | 0.002d | 0.083e | 0.183f | 0.013g | |
aPatients initiating ART.
bThis patient had less than 3 years of follow-up visits after HIV-1 infection.
The significance of the difference in agec, VL set pointd, CD4 T-cell counte, VL at 3 years after infectionf (patients initiating ART were excluded) between the two groups of individuals was assessed in Student’s t-test. Differences were considered statistically significant at P < 0.05.
gFisher’s exact test.
Y, yes; N, no; NA, not applicable; ND, not detected; HIV-1, human immunodeficiency virus type 1; HLA, human leukocyte antigen; ART, antiretroviral therapy; VL, viral load.