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Natural anticoagulants cascade and various anticoagulant agents. Antithrombin is an inactivator of thrombin and factor Xa and a major inhibitor of blood coagulation. Heparin and its derivatives act by increasing the activity of antithrombin. Rivaroxaban directly binds to the active site of Xa, blocking the activity. AT: antithrombin, II: prothromin, IIa: thrombin, UFH: unfractionated heparin, LMWH: low-molecular-weight heparin
