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Model: PANet averts the inhibition of the proteasome by soluble oligomers. 1, Gβ1 remains continuously misfolded due to the absence of Gγ1. 2, Other proteins also become misfolded because Gβ1 competitively inhibits the CCT-mediated protein-folding pathway. 3, Buildup of misfolded proteins leads to formation of soluble oligomers that inhibit the 26S proteasome. 4, PANet unfolds the misfolded proteins, which targets them to the innate Hsp70-Hsp40 and Hsp90 systems and the UPS.
