Figure 6.

Granulomatous-lymphocytic interstitial lung disease diagnostic algorithm. All patients with common variable immunodeficiency should have a high-resolution computed tomography (HRCT) of the chest to screen for pulmonary disease. If there is significant interstitial lung disease (ground glass abnormalities, nodules, and areas of consolidation), one should consider lung biopsy by video-assisted thoracoscopic surgery (VATS) for definitive diagnosis. It may be worth considering if a more easily accessible organ such as a lymph node could be useful for detection of granulomas.