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. 2018 Aug 8;9:1837. doi: 10.3389/fimmu.2018.01837

Table 1.

Histopathological features of GLILD.

Featurea Occurrence (N = 16) Severity Key features
Lymphocytic interstitial pneumonitis 100% Mild 19% Lymphocytic infiltration of variable density—peribronchiolar and interstitial
Moderate 25%
Severe 56%
Follicular bronchiolitis 100% Mild 25% Consistently present; nodular peribronchial inflammation associated with interstitial inflammation
Moderate 56%
Severe 19%
Non-necrotizing granuloma 93.75% (15/16 cases) Mild 50% Well, moderate, or poorly circumscribed; non-necrotizing, may be cuffed by lymphocytes or associated with lymphoid infiltration; random distribution
Moderate 31.25%
Severe 12.5%
Organizing pneumonia 87.5% (14/16 cases) Mild 43.75% Variable severity with Masson bodies and other typical features of COP
Moderate 37.5%
Severe 6.25%
Interstitial fibrosis 75% (12/16 cases) Mild 31.25% Variable severity from patchy to extensive areas of collagenized fibrosis
Moderate 25%
Severe 18.75%

aData from Rao et al. (81).

COP, cryptogenic organizing pneumonia; GLILD, granulomatous-lymphocytic interstitial lung disease.