Table 1.
Featurea | Occurrence (N = 16) | Severity | Key features | |
---|---|---|---|---|
Lymphocytic interstitial pneumonitis | 100% | Mild | 19% | Lymphocytic infiltration of variable density—peribronchiolar and interstitial |
Moderate | 25% | |||
Severe | 56% | |||
Follicular bronchiolitis | 100% | Mild | 25% | Consistently present; nodular peribronchial inflammation associated with interstitial inflammation |
Moderate | 56% | |||
Severe | 19% | |||
Non-necrotizing granuloma | 93.75% (15/16 cases) | Mild | 50% | Well, moderate, or poorly circumscribed; non-necrotizing, may be cuffed by lymphocytes or associated with lymphoid infiltration; random distribution |
Moderate | 31.25% | |||
Severe | 12.5% | |||
Organizing pneumonia | 87.5% (14/16 cases) | Mild | 43.75% | Variable severity with Masson bodies and other typical features of COP |
Moderate | 37.5% | |||
Severe | 6.25% | |||
Interstitial fibrosis | 75% (12/16 cases) | Mild | 31.25% | Variable severity from patchy to extensive areas of collagenized fibrosis |
Moderate | 25% | |||
Severe | 18.75% |
aData from Rao et al. (81).
COP, cryptogenic organizing pneumonia; GLILD, granulomatous-lymphocytic interstitial lung disease.