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Association between CTCs in the peripheral blood of patients with breast cancer and infiltrating intratumoral Foxp3+ Tregs. The patients with breast cancer were divided into two groups according to the median (10.33). Patients with an increased number of intratumoral Foxp3+ Tregs exhibited a higher CTC-positive rate compared with those with a lower number of Foxp3+ Tregs (67 vs. 43%, P=0.002). CTC, circulating tumor cells; Tregs, regulatory T cells; Foxp3, forkhead box 3.
