Clinical verification of mRNA expression and methylation levels of DTL, DUSP1, NFKBIA and SOCS2 in HCC tumor and paracancerous samples. (A) Comparison of tumor vs. paracancerous mRNA expression levels: DTL, P=0.0007; DUSP1, P=0.0268; NFKBIA, P=0.0008, and SOCS2, P=0.0091. (B) Comparison of tumor vs. paracancerous methylation levels: DTL, P<0.0001; DUSP1, P<0.0001; NFKBIA, P<0.0001, and SOCS2, P<0.0001. -tumor, measured in tumor samples, -para measured in paracancerous samples.