Gene expression profile and prognostic significance of three identified clusters in lung cancer. (A) Gene expression profile of three clusters in lung cancer. Unsupervised clustering of the expression of the 13 mitochondrial protein-coding genes identified 3 clusters of the 1,014 lung cancer tumor expression profiles in the left panel. The total number of LUAD and LUSC profiles in each cluster is illustrated in the right panel as a bar chart. (B) Kaplan-Meier survival curves for Clusters 1, 2 and 3 for overall lung cancer, LUAD and LUSC. (C) Gene expression profile of the three clusters in GSE81089. Unsupervised clustering of the expression of the 13 mitochondrial genes was applied to 175 lung cancer tumor expression profiles. Kaplan-Meier survival curves for Clusters 1, 2 and 3 in overall lung cancer and LUAD were drawn. LUAD, lung adenocarcinoma; LUSC, lung squamous cell carcinoma.