Table III.
Univariate analysis of 13 variables associated with DFS in patients with HCC who underwent surgical resection with curative intent (n=270).
| Variables | Cut off values | Total | Disease-free survival time (months) | P-value |
|---|---|---|---|---|
| Sex | 0.143 | |||
| Male | 228 | 14.0±2.5 | ||
| Female | 42 | 6.0±2.8 | ||
| Age (years) | 0.006 | |||
| <60 | 222 | 11.0±2.2 | ||
| ≥60 | 48 | 48.0±21.8 | ||
| Bile duct invasion | <0.001 | |||
| Yes | 107 | 8.0±1.2 | ||
| No | 163 | 33.0±9.9 | ||
| PVTT | <0.001 | |||
| Yes | 35 | 5.0±1.4 | ||
| No | 235 | 18.0±2.6 | ||
| Presence of hepatitis | 0.003 | |||
| Yes | 257 | 12.0±2.4 | ||
| No | 13 | 60.2±9.8 | ||
| Presence of cirrhosis | 0.052 | |||
| Yes | 153 | 18.0±3.4 | ||
| No | 117 | 11.0±1.9 | ||
| Tumor size (cm) | 0.021 | |||
| <5 | 99 | 21.0±2.0 | ||
| ≥5 | 171 | 9.0±1.6 | ||
| Multiple tumor lesions | 0.010 | |||
| Yes | 40 | 4.2±1.9 | ||
| No | 230 | 17.0±2.8 | ||
| AFP (ng/ml) | <0.001 | |||
| <20 | 89 | 43.0±7.4 | ||
| ≥20 | 181 | 9.0±1.4 | ||
| PT (sec) | 0.328 | |||
| <14 | 249 | 14.0±2.6 | ||
| ≥14 | 21 | 10.0±3.6 | ||
| TBIL (mg/dl) | 0.001 | |||
| <2 | 203 | 18.0±5.7 | ||
| ≥2 | 67 | 8.0±2.0 | ||
| ALB (g/l) | 0.001 | |||
| <35 | 22 | 3.6±3.2 | ||
| ≥35 | 248 | 16.0±2.5 | ||
| ALT (U/l) | 0.039 | |||
| <40 | 99 | 18.0±11.9 | ||
| ≥40 | 171 | 12.0±2.4 |
DFS, disease-free survival; HCC, hepatocellular carcinoma; TBIL, total bilirubin; PVTT, portal vein tumor thrombosis; ALB, albumin; ALT, alanine transaminase; PT, prothrombin time; AFP, α-fetoprotein.