Table I.
Hepatocellular carcinoma patients' characteristics stratified by PKM2 expression.
| PKM2 expression | |||
|---|---|---|---|
| Patient characteristics | High (≥11.25) | Low (<11.25) | P-value |
| Sex, n (%) | <0.001 | ||
| Male | 107 (57.8) | 142 (76.8) | |
| Female | 78 (42.2) | 43 (23.2) | |
| Diagnosis age, years | 58.4±14.3 | 60.5±12.7 | 0.129 |
| Height, cm | 166.7±9.6 | 168.6±8.6 | 0.057 |
| Weight, kg | 71±20.2 | 74.6±18.6 | 0.087 |
| Body mass index, kg/m2 | 25.5±6.8 | 26.1±5.5 | 0.397 |
| Creatinine, mg/dl | 1.1±1.0 | 2.8±10.9 | 0.043 |
| Fetoprotein, ng/ml (log2 converted) | 6.8±5.0 | 4.1±3.4 | <0.001 |
| Albumin, g/dl | 3.9±0.9 | 4.4±5.6 | 0.149 |
| Race, n (%) | 0.973 | ||
| Asian | 76 (42.5) | 81 (44.8) | |
| White | 93 (52.0) | 91 (50.3) | |
| Black/African American | 9 (5.0) | 8 (4.4) | |
| American Indian/Alaska Native | 1 (0.6) | 1 (0.6) | |
| Residual tumor, n (%) | 0.181 | ||
| R0 | 154 (92.8) | 170 (96.6) | |
| R1/R2 | 12 (7.2) | 6 (3.4) | |
| Vascular tumor invasion | 0.094 | ||
| None | 90 (60.4) | 116 (69.9) | |
| Micro | 48 (32.2) | 45 (27.1) | |
| Macro | 11 (7.4) | 5 (3) | |
| Adjacent hepatic tissue inflammation | 0.268 | ||
| None | 53 (50.0) | 64 (50.0) | |
| Mild | 48 (45.3) | 51 (39.8) | |
| Severe | 5 (4.7) | 13 (10.2) | |
| Stage, n (%) | <0.001 | ||
| I | 65 (38) | 106 (59.9) | |
| II | 51 (29.8) | 35 (19.8) | |
| III | 50 (29.2) | 35 (19.8) | |
| IV | 5 (2.9) | 1 (0.6) | |
| Grade, n (%) | 0.004 | ||
| 1 | 19 (10.3) | 36 (19.8) | |
| 2 | 83 (45.1) | 94 (51.6) | |
| 3 | 76 (41.3) | 46 (25.3) | |
| 4 | 6 (3.3) | 6 (3.3) | |
PKM2, pyruvate kinase muscle isozyme M2.