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Schematic diagram of the establishment of the cell lines. A hepatocellular carcinoma PDX model LIX-004 was subjected to daily treatment with vehicle or sorafenib. Cell lines, LIXC-004NA (from a tumor of the vehicle-treated group) and LIXC-004SR (from a tumor developed following ~100 days of treatment with sorafenib), were established. PDX, patient-derived tumor xenograft; Sora, sorafenib.
