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. 2018 Aug 10;12:545. doi: 10.3389/fnins.2018.00545

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Copyright © 2018 Nyarko, Quartey, Heistad, Pennington, Poon, Knudsen, Allonby, El Zawily, Freywald, Rauw, Baker and Mousseau.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Representative immunoblots of key indicies of the 5-HT synapse in human frontal cortex. The expression of the 5-HT transporter (5-HTT), the vesicular monoamine transporter (VMAT2), the presynaptic marker, SNAP-25, the post-synaptic marker, PSD-95, and the post-synaptic 5-HT2C receptor are shown. Levels of protein loading were monitored by probing for GSK-3α/β. CTL: control; EO (early-onset) and LO (late-onset) AD (Alzheimer disease). In the 5-HTT panel, the numbers in parentheses (at left) identify the molecular weights of specific 5-HTT bands (some highlighted with curly brackets) that were used for densitometry and analysis. Arrowheads represent molecular weights of protein standards/ladders.