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. 2018 Aug 10;12:545. doi: 10.3389/fnins.2018.00545

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Copyright © 2018 Nyarko, Quartey, Heistad, Pennington, Poon, Knudsen, Allonby, El Zawily, Freywald, Rauw, Baker and Mousseau.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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5-HTT genotyping. (A) Standard PCR was used to amplify the 5-HTTLPR (spans the region of the promoter in which a 44 bp sequence is present or deleted) and amplicons were resolved on 2% agarose gel to determine whether the sample contains only the long allele (L/L: 419 bp), only the short allele (S/S: 375 bp), or both (S/L). (B) The frequency of the allelic variants (i.e., S/S, S/L and L/L) in our 60 brain samples. (C) The distribution was as expected in the control (CTL) samples; however, the Early-Onset AD (EOAD) or Late-Onset AD (LOAD) samples were not associated with any significantly higher number of the S allele.