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miR-21 biogenesis. miR-21 is transcribed from chromosome 17 into pri-miR-21 transcripts, which are processed into hairpin precursor molecules (pre-miR-21) inside the nucleus. These are then further processed into mature miR-21 sequences in the cytoplasm of eukaryotic cells, which are incorporated into the RISC and guided to miR-21 target mRNAs to repress their expression. miR, microRNA; pre-miR, precursor miRNA; pri-miR, primary miRNA; RISC, RNA-induced silencing complex.
