FIG. 4.

Commonly upregulated genes across species and tissue types. (A) Three-way Venn diagram of upregulated genes reveals identification of eight unique genes that are commonly upregulated across mouse and human MSCs. (B) Table derived from DAVID functional annotation tool listing top eight gene annotation cluster terms, counts, and P values. Of significant importance are representative GO terms including skeletal muscle development, bone development, ossification, tissue morphogenesis and angiogenesis. (C) STRING v10.5 network analysis illustrates that these genes are standalone and show no reported networks or connectivity between the eight genes. (D) Summary and description of previous findings of the panel of eight genes consistently modulated by CytoD independent of species or cell type. DAVID, Database for Annotation, Visualization and Integrated Discovery; GO, gene ontology. Color images available online at www.liebertpub.com/scd