Fig. 5. C-Glycosidic second generation of structural analogues of the natural product phlorizin (2) approved for therapeutic use as SGLT-2 inhibitors. The C-glycosidic bond is highlighted in red; the lipophilic substituent in the para position to this bond is highlighted in green in derivatives 1 and 11–15; ring B and its substituents are highlighted in pink for all the derivatives; and the modifications made in the glycosidic subunit in derivatives 13, 15 and 16 are highlighted in blue.
