Table 4.
Methylation of the promoter region of genes related to esophageal cancer in Kazakh patients
| Gene | Group | No methylation n (%) |
Partial methylation n (%) |
Methylation n (%) |
Total | χ2 | P-value |
|---|---|---|---|---|---|---|---|
| MTHFR | Exp. | 82 (42.7) | 61 (31.8) | 49 (25.5) | 192 | 45.144 | <0.001 |
| Control | 152 (76.0) | 26 (13.0) | 22 (11.0) | 200 | |||
| CBS | Exp. | 158 (82.3) | 19 (9.9) | 15 (7.8) | 192 | 18.465 | <0.001 |
| Control | 168 (84.0) | 32 (16.0) | 0 (0.0) | 200 | |||
| MGMT | Exp. | 137 (71.4) | 49 (25.5) | 6 (3.1) | 192 | 11.853 | 0.003 |
| Control | 153 (76.5) | 29 (14.5) | 18 (9.0) | 200 | |||
| P16 | Exp. | 105 (54.7) | 63 (32.8) | 24 (12.5) | 192 | 37.359 | <0.001 |
| Control | 166 (83.0) | 22 (11.0) | 12 (6.0) | 200 | |||
| FHIT | Exp. | 100 (52.1) | 48 (25.0) | 44 (22.9) | 192 | 46.608 | <0.001 |
| Control | 162 (81.0) | 32 (16.0) | 6 (3.0) | 200 | |||
| RASSF1A | Exp. | 112 (58.3) | 66 (34.4) | 14 (7.3) | 192 | 14.766 | 0.001 |
| Control | 153 (76.5) | 39 (19.5) | 8 (4.0) | 200 |
Abbreviations: Exp.: experimental; χ2: Chi-square.